The International Journal of Ayurvedic Formulations and Pharmacological Research (IJAFPR) is committed to consistently publishing high-quality, peer-reviewed articles that contribute to the evolving body of knowledge in Ayurvedic formulations and pharmacological studies. This section provides access to the latest research as well as a comprehensive archive of all previously published issues.
Featured Articles in the Latest Issue
- Volume 2 (Issue 1) JANUARY- JUNE 2026
Research Articles
Standardization and Anti-Inflammatory Evaluation of a Polyherbal Ayurvedic Decoction for Rheumatoid Arthritis
Vol.2(1); Pages:1-8. Published on March-2026
Abstract
This study investigates the anti-inflammatory efficacy and standardization parameters of a traditional Ayurvedic polyherbal decoction indicated for rheumatoid arthritis. The formulation, comprising botanicals with documented Rasayana and anti-inflammatory properties, was subjected to physicochemical analysis, phytochemical screening, and chromatographic profiling. In vitro assays assessed inhibition of pro inflammatory cytokines including TNF-α and IL-6 in stimulated macrophage cell lines. Subsequently, an in vivo model using collagen-induced arthritis in rodents evaluated therapeutic outcomes, including joint swelling, histopathological changes, and biomarker expression. Results demonstrated significant suppression of inflammatory mediators and improved joint architecture compared to control groups. Standardization ensured batch-to-batch consistency, validating reproducibility. The integration of traditional knowledge with modern pharmacological techniques underscores the potential of Ayurvedic formulations as complementary therapeutic agents in chronic inflammatory diseases. These findings support further clinical evaluation and highlight the importance of rigorous scientific validation in traditional medicine research.
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Bioavailability Enhancement of Curcumin through Ayurvedic Liposomal Formulation Techniques
Vol.2(1); Pages:9-19. Published on March-2026
Abstract
Curcumin, a bioactive compound derived from turmeric, exhibits significant pharmacological properties but suffers from poor bioavailability. This study aimed to enhance curcumin absorption using Ayurvedic-inspired liposomal delivery systems. The formulation incorporated phospholipids and natural bioenhancers aligned with traditional Sneha Kalpana principles. Particle size analysis, zeta potential measurement, and encapsulation efficiency were evaluated to optimize the formulation. Pharmacokinetic studies in animal models revealed a marked increase in plasma concentration and prolonged half-life compared to conventional curcumin preparations. Additionally, antioxidant and anti-inflammatory activities were significantly enhanced, indicating improved therapeutic efficacy. The study bridges classical Ayurvedic formulation strategies with modern nanotechnology, offering a promising approach to overcome bioavailability challenges. These findings may contribute to the development of more effective herbal therapeutics and support the integration of traditional knowledge into contemporary drug delivery systems.
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Clinical Evaluation of an Ayurvedic Herbal Oil in the Management of Chronic Insomnia
Vol.2(1); Pages:20-28. Published on April-2026
Abstract
Chronic insomnia is a prevalent disorder with significant health implications. This randomized controlled trial evaluated the efficacy of an Ayurvedic herbal oil administered through Shiroabhyanga (head massage) in improving sleep quality. Participants were randomly assigned to intervention and control groups, with the former receiving nightly application of the herbal oil for six weeks. Outcome measures included sleep latency, total sleep time, and subjective sleep quality assessed through validated questionnaires. Biochemical markers such as cortisol levels were also monitored. The intervention group demonstrated significant improvements in sleep parameters and reduced stress indicators compared to controls. The herbal oil’s constituents, known for their calming and Vata-pacifying properties, likely contributed to the observed effects. This study provides clinical evidence supporting the use of Ayurvedic therapies in managing sleep disorders and emphasizes the need for integrative approaches in modern healthcare.
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Toxicological Assessment of a Traditional Ayurvedic Metal-Based Formulation Using Modern Analytical Techniques
Vol.2(1); Pages:29-37. Published on May-2026
Abstract
Metal-based Ayurvedic formulations, known as Rasaushadhis, have long been used therapeutically, yet concerns regarding their safety persist. This study conducted a comprehensive toxicological evaluation of a classical formulation containing processed metals. Advanced analytical techniques, including ICP-MS and XRD, were employed to characterize elemental composition and particle size. Acute and sub-chronic toxicity studies were performed in animal models, assessing hematological, biochemical, and histopathological parameters. Results indicated no significant toxicity at therapeutic doses, with organ function remaining within normal limits. Proper purification and processing methods, as described in classical texts, were found to be critical in ensuring safety. The study reinforces the importance of adhering to traditional preparation protocols while utilizing modern tools for validation. These findings contribute to the evidence base supporting the safe use of Rasaushadhis in clinical practice.
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Comparative Antioxidant Activity of Ayurvedic Herbal Extracts Using DPPH and FRAP Assays
Vol.2(1); Pages:38-46. Published on May-2026
Abstract
Oxidative stress plays a crucial role in the pathogenesis of numerous chronic diseases. This study aimed to compare the antioxidant potential of selected Ayurvedic herbal extracts using DPPH and FRAP assays. Extracts from commonly used medicinal plants were prepared using standardized protocols and subjected to quantitative analysis of phenolic and flavonoid content. Results demonstrated significant variability in antioxidant activity, with certain extracts exhibiting superior free radical scavenging and ferric reducing capabilities. Correlation analysis revealed a strong association between phytochemical content and antioxidant efficacy. The findings highlight the therapeutic potential of these herbs in mitigating oxidative damage and support their inclusion in preventive healthcare strategies. The study underscores the value of systematic evaluation of traditional remedies using modern scientific methodologies.
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