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Volume 1
Issue 2 JULY– DECEMBER 2025
Volume 1 (Issue 2) JULY– DECEMBER 2025 Research Articles
An integrative pharmacognostic study on Formulation and Standardization of a Polyherbal Churna in the Management of Hyperlipidemia
Vol.1(2); Pages:1-8. Published on July-2025
Abstract
Ayurveda has centuries long experience of using polyherbal formulations to address lifestyle disorders such as hyperlipidemia. The objective of the present research was to design, assess and standardize a churna of Terminalia arjuna, Commiphora mukul and Trigonella foenum-graecum to be used in the treatment of hyperlipidemia. Botanical identification was applied to authenticate the raw materials; organoleptic, microscopic and physicochemical analyses were used to determine quality of the materials. The final formulation was standardized by determining the total amount of tannin, saponin and guggulsterone content by High-Performance Thin-Layer Chromatography (HPTLC) techniques. The ability of the formulation to lower lipid was studied in vitro by inhibiting pancreatic lipase, where the churna inhibited it to the tune of 68.3% at the concentration of 250 µg/mL. This research describes an integrative approach to the development of Ayurvedic formulations that involves the traditional pharmacognostic methodology along with the modern analytical technique to assure quality and efficacy. These findings confirm that this polyherbal churna has a strong potential to be used in the management of hyperlipidemia in compliance with the modern pharmaceutical standards.
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Standardization and Clinical Assessment of Ashwagandha Root Extract on Pediatric Anxiety: A Pilot Randomized Controlled Trial
Vol.1(2); Pages:9-18. Published on October-2025
Abstract
The classical Ayurvedic adaptogen, Withania somnifera (Ashwagandha) has also been shown to be effective in the treatment of stress and anxiety. This pilot, randomized, controlled trial measured the safety and efficacy of a standardized Ashwagandha root extract in children with mild-to-moderate anxiety aged 8 -14 years. Forty subjects were randomly assigned to take either placebo or 300 mg of Ashwagandha twice/day over a period of 8 weeks. The reduction in Pediatric Anxiety Rating Scale (PARS) scores was the primary outcome, whereas the secondary measures were the sleep quality and adverse events. The Ashwagandha group reported a reduction in anxiety scores of 32% compared to 12 in the placebo (p<0.05) with a large improvement in sleep. Only minor gastrointestinal symptoms of the extract were noted as the extract was well tolerated. The results indicate that Ashwagandha has the prospect of use as a safe, plant-based pediatric anxiolytic.
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Pharmacognostic and Phytochemical Analysis of Brahmi Extracts that belong to Different Climatic Zones
Vol.1(2); Pages:19-28. Published on November-2025
Abstract
There is Ayurvedic glory of Welvezia somnifera (Bacopa monnieri, or Brahmi) high on its cognitive-enhancing effects. The objective of this experimental comparative study was to find out whether the climate (tropical, temperate, and arid) makes a difference in the phytochemical composition of Brahmi samplings. HPTLC and bacoside A quantification showed a large regional variability, where most of the tropical-origin samples had the highest bacoside A content (3.8%) followed by temperate (2.4%) and arid (1.9%) ones. The bacosides were positively correlated with memory-enhancing activity as measured using the murine behavioral maze tests. The results identify the importance of the geo-climatic conditions in the potency of herbs and recommend the standardization of supply, climate-based production of Ayurvedic drugs, and pharmacognosticscreening of Ayurvedic products.
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Comparative Clinical Efficacy of an Ayurvedic Polyherbal Serum with Proton Pump Inhibitors in Functional Dyspeptic Patients
Vol.1(2); Pages:29-39. Published on November-2025
Abstract
Functional dyspepsia (FD) is a common gastrointestinal condition of chronic upper abdominal pain and compromised digestion. In this prospective, randomized clinical trial, the FD patients (92 adults) were randomized to either Ayurvedic polyherbal formulation which contained Haritaki (Terminalia chebula), Sunthi (Zingiber officinale) and Guduchi (Tinospora cordifolia) or standard proton pump inhibitor (PPI) therapy. The different groups of participants were given either the herbal form of dietary supplement (500 mg twice a day) or omeprazole (20 mg daily) and followed them through a six-week study. Both groups had a significant decrease in the symptoms (65 percent Ayurvedic, 68 percent PPI; p = 0.42). The Ayurvedic group also experienced enhanced appetite and digestion and fewer side effects. We recommend Ayurvedic treatment as one of the safe, well-tolerable and potentially effective options to manage FD, especially in patients who are more interested in holistic or long-term management approaches.
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Systematic Review and Meta-Analysis of herbal interventions in Ayurveda in the treatment of diabetes type 2
Vol.1(2); Pages:40-48. Published on December-2025
Abstract
This systematic review and meta-analysis evaluated the effect and safety of Ayurvedic herbal preparations in the management of Type 2 Diabetes Mellitus (T2DM). The analysis of 19 clinical trials with 1,142 patients was studied, which focused on the herbs Gymnema sylvestre (Gurmar), Momordica charantia (Bitter melon) and Trigonella foenum-graecum (Fenugreek). The findings revealed the significant decrease in fasting blood glucose (18.6 mg / dL ) and HbA1c ( 0.6 % ) compared to controls. The treatment based on Gmyema uniformly enhanced glucemia, and Momordica resulted in effective reduction of post-prandial glucose. The side effects were of mild intensity (mainly gastrointestinal). The data are further limited by the study heterogeneity and the trial quality but, these results indicate potential of the Ayurvedic interventions to be effective and safe adjuncts used in conventional diabetes treatment. Standard, high-quality RCTs are urgently required to valid these effects, and facilitate their inclusion as part of global treatment guidelines.
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Issue 1 JANUARY- JUNE 2025
Volume 1(Issue 1) JANUARY- JUNE 2025 Research Articles
Emerging Perspectives on Plumbago zeylanica: Combatting Antimicrobial Resistance and Exploring Therapeutic Potentials
Vol.1(1); Pages:1-8. Published on June-2025
Abstract
For many centuries, Plumbago zeylanica which is also referred to as Chitraka, has been significant in Ayurveda because of its numerous medical uses. The review reviews the phytopharmacological actions of P. zeylanica and its beneficial compounds, pointing out its strong potential in addressing antibiotic resistance by employing plasmid curing. Some important secondary metabolites (plumbagin and lawsone) present in this plant show good antimicrobial, antioxidant, anti-inflammatory, anticancer, antidiabetic and leishmanicidal effects. Since there is a global concern about multidrug-resistant bacteria, the power of P. zeylanica extracts to eliminate resistanceproviding plasmids is a safe and new way to restore the effectiveness of available antibiotics. This review combines research from the past with recent science to show that P. zeylanica carries important benefits for both integrative and preventive medicine.
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A Synergistic Herbal Preparation from Ayurveda for Kidney Dysfunction
Vol.1(1); Pages:9-17. Published on June-2025
Abstract
If we talk about Chronic Kidney Disease (CKD), it involves lasting problems in the kidneys which may include reduced nephron function and higher risk of heart disease. Punarnavadi Kwath contains nine classical Ayurvedic herbs such as Boerhavia diffusa, Berberis aristata, Curcuma longa, Zingiber officinale, Terminalia chebula, Tinospora cordifolia, Plumbago zeylanica, Clerodendrum serratum and Cedrus deodara. Their antiinflammatory, diuretic, antioxidant and nephroprotective features assist in reducing the issues like inflammation, watery legs and high levels of serum creatinine and urea in people with CKD. The review brings together information on how each ingredient affects the body through studies and clinical experiments. It also points out the therapeutic value, safety and the right use of Punarnavadi Kwath for treating CKD and putting off the need for dialysis or renal transplantation..
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Fixed Dose Combinations as a Paradigm for Enhancing Therapeutic Efficiency: A Comprehensive Overview
Vol.1(1); Pages:18-25. Published on June-2025
Abstract
Through the use of FDCs, the administration of multiple active ingredients is possible in just one dosage form to aid in achieving the best treatment results. It investigates the key ideas, clinical applications and how FDCs are used to increase treatments’ results, patient commitment and save money, especially for chronic or comorbid illnesses. This paper highlights the key importance of FDCs by explaining how formulation, regulations and personalized medicine issues affect them. The review mentions interesting design strategies and talks about new ways FDCs could have an impact on global healthcare.
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Holistic Ayurvedic Intervention in Childhood Bronchial Asthma: Evidence from an Individual Case Report
Vol.1(1); Pages:26-33. Published on June-2025
Abstract
Tamaka Shwasa is also called bronchial asthma and is described as a chronic disease with frequent breathlessness, wheezing and cough. In Ayurveda, it is counted as a kind of Shwasa Roga and typically makes managing children’s cases difficult and requires repeated care. This case is of a 7-year-old male child diagnosed with Tamaka Shwasa. Doctors followed an Ayurvedic method in treating the child by giving herbs and adjusting lifestyle choices to help balance the aggravated doshas. People reported improved symptoms including difficulty in breathing, coughing fits and restless sleep. Through this case, it is clear that Ayurveda may offer children with asthma a better and healthier alternative to standard treatments.
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Pharmacological and Toxicological Duality of Helleborus Species: Therapeutic Potential Versus Cardiotoxic Risk
Vol.1(1); Pages:34-41. Published on June-2025
Abstract
The Helleborus genus which is part of the Ranunculaceae family, includes plants that have been used in the past for their strong pharmacological and poisonous qualities. This report will focus on studying traditional uses, the plant’s chemical components and the potential medical effects of different Helleborus species, especially Helleborus odorus Waldst. et Kit. Active compounds in a plant’s roots and their roles in several therapeutic actions, are emphasized. Among these are activities such as increasing heart power, strengthening the immune system, fighting against bacteria, fighting tumors, helping the body eliminate excess fluids and causing vomiting. The pharmacological importance of Helleborus is shown by its secondary metabolites such as bufadienolides, flavonoids and phenolic glycosides. Even though they can be used for medical purposes, these plants are quite toxic, so they must be handled with care in drugs. All in all, Helleborus plants are significant and complicated tools used in the field of pharmacology.
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