Welcome to the Current Issues section of JPDST. This page offers access to the latest research and previously published volumes that explore cutting-edge developments in pharmaceutical devices, smart drug delivery systems, digital therapeutics, and allied disciplines.
Featured Articles in the Latest Issue
- Volume 2 (Issue 1) JANUARY- JUNE 2026
Research Articles
Smart Polymeric Implants for Controlled Insulin Delivery in Type 1 Diabetes
Vol.2(1); Pages:1-8. Published on April-2026
Abstract
The development of smart polymeric implants has significantly advanced the field of controlled drug delivery for chronic diseases such as Type 1 diabetes. This study investigates a glucose-responsive polymeric implant capable of modulating insulin release in real time based on physiological glucose levels. The implant was fabricated using a biocompatible hydrogel matrix embedded with glucose oxidase and insulin-loaded nanoparticles. In vivo experiments conducted on diabetic rodent models demonstrated a sustained and self regulated insulin release over a 30-day period. Blood glucose levels remained within normoglycemic ranges without the need for external intervention. The device exhibited minimal inflammatory response and maintained structural integrity throughout the study duration. Comparative analysis with conventional insulin injections revealed superior glycemic control and reduced hypoglycemic episodes. The findings suggest that smart polymeric implants could provide a promising alternative to traditional insulin therapy, improving patient compliance and quality of life. Further clinical trials are warranted to validate long-term safety and efficacy in human subjects.
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Integration of Nanobiosensors in Wearable Therapeutic Devices for Cardiovascular Monitoring
Vol.2(1); Pages:9-17. Published on April-2026
Abstract
Wearable therapeutic devices integrated with nanobiosensors represent a transformative approach in cardiovascular health monitoring. This study evaluates the performance of a wearable patch embedded with nanoscale electrochemical sensors designed to detect biomarkers such as troponin and lactate in real time. A cohort of 120 patients with a history of cardiovascular disease was monitored over a three-month period. The device demonstrated high sensitivity and specificity in detecting early signs of cardiac distress, with rapid signal transduction and minimal signal drift. Data collected were wirelessly transmitted to a cloud-based platform for continuous analysis and physician review. The integration of therapeutic feedback mechanisms enabled timely drug release in response to abnormal biomarker levels. Patient compliance was notably high due to the device’s non-invasive design and ease of use. The study highlights the potential of nanobiosensor-enabled wearables in proactive disease management and personalized therapy. Future work will focus on miniaturization and expanding biomarker detection capabilities.
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AI-Driven Smart Inhalers for Precision Drug Delivery in Asthma Management
Vol.2(1); Pages:18-27. Published on May-2026
Abstract
Artificial intelligence (AI)-driven smart inhalers have emerged as innovative tools for enhancing asthma management through precision drug delivery. This randomized controlled trial assessed the efficacy of an AI enabled inhaler system that tracks usage patterns, environmental triggers, and patient adherence. A total of 200 asthma patients were divided into intervention and control groups over a 12-week period. The smart inhaler utilized machine learning algorithms to provide personalized dosing recommendations and real-time feedback. Results indicated a significant reduction in asthma exacerbations and improved lung function in the intervention group compared to controls. Additionally, adherence rates increased by 35%, attributed to automated reminders and usage analytics. The system also enabled remote monitoring by healthcare providers, facilitating timely interventions. The integration of AI in inhalation therapy demonstrates substantial potential in optimizing treatment outcomes and reducing healthcare costs. Further studies are needed to evaluate long term benefits and scalability in diverse populations.
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Biodegradable Microchip-Based Drug Delivery Systems for Targeted Cancer Therapy
Vol.2(1); Pages:28-38. Published on May-2026
Abstract
Targeted cancer therapy has greatly benefited from advancements in microchip-based drug delivery systems. This study explores a biodegradable microchip platform capable of delivering chemotherapeutic agents directly to tumor sites with controlled release kinetics. The microchip consists of multiple reservoirs loaded with doxorubicin, sealed with biodegradable membranes that dissolve at predetermined intervals. In vivo studies conducted on murine tumor models demonstrated precise spatial and temporal drug release, resulting in significant tumor regression with minimal systemic toxicity. Histopathological analysis confirmed reduced damage to healthy tissues compared to conventional chemotherapy. The device’s biodegradability eliminates the need for surgical removal, enhancing patient safety and comfort. Additionally, the programmable nature of the microchip allows for customization of treatment regimens based on tumor progression. These findings underscore the potential of microchip-based systems in revolutionizing cancer treatment. Future research will focus on clinical translation and integration with real-time tumor monitoring technologies.
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Smart Transdermal Patches with Responsive Drug Release for Pain Management
Vol.2(1); Pages:39-48. Published on June-2026
Abstract
Smart transdermal patches with responsive drug release mechanisms offer a novel approach to pain management by delivering therapeutics in a controlled and patient-specific manner. This study compares the efficacy of a temperature- and pH-responsive transdermal patch with conventional opioid-based therapies in patients suffering from chronic pain conditions. The patch incorporates a multilayered with embedded sensors that detect physiological changes and trigger drug release accordingly. Clinical evaluation involving 150 patients revealed that the smart patch provided consistent pain relief with reduced side effects and lower dependency risks. Patients reported improved quality of life and higher satisfaction due to the non-invasive and self-regulating nature of the device. Pharmacokinetic analysis showed stable plasma drug concentrations, minimizing peaks and troughs associated with traditional dosing. The results indicate that responsive transdermal systems can serve as effective alternatives to conventional pain therapies. Further large-scale studies are recommended to validate long-term safety and broader applicability.
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