The Journal of Innovative Therapeutics and Drug Care (JITDC) is committed to publishing timely and impactful research that shapes the future of pharmaceutical science and clinical drug management. Our archives serve as a valuable resource for researchers, practitioners, educators, and students across the globe.
Featured Articles in the Latest Issue
- Volume 2 (Issue 1) JANUARY- JUNE 2026
Research Articles
Targeted Nanocarrier Systems for Enhanced Delivery of Antiviral Agents in Respiratory Infections
Vol.2(1); Pages:1-10. Published on April-2026
Abstract
Antiviral drug delivery has also been enhanced greatly by the creation of specific nanocarrier systems especially in cases of respiratory infections. This paper examines carriers using polymeric nanoparticles that have been developed to improve antiviral delivery due to their bioavailability and localized delivery to target sites. With the help of the in vitro cellular uptake assays and in vivo murine models, the efficacy of encapsulated antiviral compounds was compared against conventional formulations. Findings showed that there were 2.7-fold higher levels of pulmonary retention of drugs and a significant decrease in systemic toxicity. The nanoparticles had regulated release dynamics and enhanced mucosal uptake, resulting in prolonged remedial concentrations on infection foci. Additionally, animal models with treatment experienced great viral load and inflammatory markers lowering than control groups. The paper shows the possibility of nanocarrier-based delivery systems to overcome pharmacokinetic issues of antiviral drugs. These results contribute to the further clinical translation of therapeutics against respiratory viral diseases using nanoparticles, which proves a promising solution in enhancing outcomes of treatment and patient adherence.
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Pharmacogenomic Profiling in Personalized Oncology: A Multicenter Cohort Analysis
Vol.2(1); Pages:11-19. Published on May-2026
Abstract
Pharmacogenomic profiling has become a pillar of personalized oncology and it has allowed customized therapeutic approaches on genetic variability. It was a multicenter cohort study assessing the effect of pharmacogenomic -guided therapy on the efficacy of treatment and adverse drug reactions in patients with cancer. There were 420 participants representing three European centers and genetic screening was done on the important drug-metabolizing enzymes and transporters. The patients undergoing the genotype-guided therapy showed 35 percentage of improvement in the response rates of therapy and a substantial decrease in the adverse events in grade III/IV. In the case of drug metabolism efficiency, the statistical analysis showed that there are strong correlations between particular genetic polymorphisms and drug metabolism efficiency. The incorporation of pharmacogenomic data in clinical decision-making led to the optimization of doses and accuracy of therapy. This paper highlights the clinical value of pharmacogenomics in cancer care and supports its application in the treatment process as a matter of routine. The results are added to the accumulating data on the effectiveness of precision medicine as a paradigm shift in cancer treatment.
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Development of Biodegradable Hydrogel-Based Implants for Sustained Drug Release in Chronic Pain Management
Vol.2(1); Pages:20-29. Published on May-2026
Abstract
The management of chronic pain is usually associated with long-term drug use, which creates the problem of patient compliance and systemic adverse effects. This paper outlines the creation and analysis of the biodegradable hydrogel-based implants to release drugs in the long-term. Biocompatible polymers were used to synthesize the hydrogels to be loaded with analgesic agents. In vitro release studies showed controlled release profile up to 28 days whereas in vivo rodent model implantation supported biocompatibility and efficient pain relief. Histology showed that there was little inflammatory reaction, and the implant material was degraded slowly. Drug plasma concentration was stable, which led to the elimination of frequent dosing as a result of pharmacokinetic studies. The proposed system provides a less invasive approach to the standard therapies, increasing the comfort of the patients and treatment effectiveness. These results indicate that implants containing hydrogel have a high potential in the application of long-term pain control interventions, and therefore, should be considered during clinical research.
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AI-Enabled Therapeutic Reassignment Strategies for Neurodegenerative Disease Management
Vol.2(1); Pages:30-39. Published on June-2026
Abstract
Drug repurposing offers a cost-effective strategy for identifying new therapeutic uses for existing drugs, particularly in neurodegenerative disorders. This study կիրառes artificial intelligence (AI)-based algorithms to analyze large-scale biomedical datasets and identify candidate compounds for repurposing. Machine learning models were trained on drug-target interaction data and validated using known therapeutic outcomes. The analysis identified several FDA-approved drugs with high binding affinity to key proteins implicated in Alzheimer’s and Parkinson’s diseases. Molecular docking and pathway analysis further supported the therapeutic potential of these candidates. The AI-driven approach significantly reduced the time required for candidate identification compared to traditional methods. The study demonstrates the effectiveness of integrating computational tools in drug discovery pipelines, highlighting their role in accelerating therapeutic innovation. These findings pave the way for experimental validation and potential clinical application of repurposed drugs in neurodegenerative disease management.
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Evaluation of Novel Oral Insulin Formulations Using Lipid-Based Carriers: A Randomized Preclinical Study
Vol.2(1); Pages:40-49. Published on June-2026
Abstract
The oral administration of insulin is still a very problematic aspect since the insulin gets broken down by enzymes and is not efficiently absorbed in the intestines. The research appraises lipid based carrier systems that would improve the stability and bioavailability of oral insulin preparations. A randomized preclinical trial was done in diabetic rat models to compare the effectiveness of the lipid-encapsulated insulin to that of the subcutaneous administration. Findings showed that there was a significant increase in the glycemic control and that oral formulations had up to 65 percent bioavailability compared to injectable insulin. The lipid carriers spared insulin the gastrointestinal degradation and allowed it to enter through the trans-epithelial. Also the treated subjects experienced better metabolism with less variation in blood glucose level. The article brings out the possibility of the lipid based delivery system as an alternative to injectable insulin, where better patient adherence and quality of life are realized. The optimization of the formulation parameters and evaluation of the long-term safety in clinical settings should be optimized through further research.
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