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Volume 1
Issue 2 JULY– DECEMBER 2025
Volume 1 (Issue 2) JULY– DECEMBER 2025 Research Articles
2020 Consensus Recommendations for an Updated Framework for Advanced Clinical Pharmacy Practice in Critical Care
Vol.1(2); Pages:1-7. Published on July-2025
Abstract
The current position paper is an evidence-based modernization of the original 2000 guidance on critical care pharmacy services. The updated recommendations are the result of a multiorganizational effort by the major pharmacy and critical care societies, and they capture the changing standards and advancements in the pharmacy practice in intensive care units (ICUs). Through a systematic consensus method, 82 practice recommendations were developed and sorted into five domains direct patient care, quality improvement, research and scholarship, education and training, and professional development. These guidelines differentiate the key practices that are basic and those that are desirable, depending on the different levels of ICU and institutional environments. The paper highlights the strategic value of critical care pharmacists in achieving optimization of medication therapy, improvement of patient safety and interdisciplinary care. It advocates institutional implementation and continuous review of these suggestions in order to improve quality and consistency of care of the critically ill.
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Multi-country Implementation Study Rapid Deployment of Mobile Pharmacy Units in Disaster Zones
Vol.1(2); Pages:8-15. Published on July-2025
Abstract
Healthcare delivery that involves the access of essential medicines during disasters has a very serious role to play but it is often disrupted in a crisis environment. This paper assesses the implementation of mobile pharmacy units (MPUs) in three countries affected by disasters- Pakistan (floods), Sweden (wildfires) and the Philippines (typhoon recovery) as a scalable option in disruption of pharmaceutical services. Every MPU was fitted with essential medicines that were recommended by WHO, cold-chain storage as well as real-time soft digital inventory. Within 6 months duration, the MPU handling 18,500 patients were able to provide reach to 92 percent of the essential drugs and took an average of 48 hours to get deployed. High rates of patient satisfaction were observed as 88 percent of them evaluated services as affordable and trustful. Cross-country outcomes confirm that MPUs are a fast-deployed system, culturally responsive, and that they become assimilated in national emergency systems. The research gives credence to the view that MPUs is a strong and efficient strategy in maintaining pharmaceutical services in areas faced with disaster.
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Improving Emergency Vaccine Logistics In Humanitarian Crisis Via Cold Chain Drones
Vol.1(2); Pages:16-24. Published on July-2025
Abstract
Maintaining vaccine cold-chain during humanitarian emergencies is problematic in terms of logistic barriers mainly in conflict-prone areas or areas with poor infrastructure. This pilot feasibility study tested the application of cold-chain-equipped drones to deliver measures-up to 12 remote sites in Venezuela and South Sudan over a 3-month course of time. Drones were programmed to have an internal temperature of 2-8 o C over 8 hours and were monitored in terms of the durability, flight distance, Call path performance, and heat compliance. There were successful deliveries in 96 percent of the deliveries and no cold-chain breaches. Wastage of the vaccine was also lessened by 38 percent as compared to the common land transportation. Interventions of healthcare workers revealed heavy reliance upon and interest in the scale-up. The results back the idea of introducing cold-chain drones as a flexible and scalable logistic element of emergency vaccination that can be adopted in humanitarian settings where the traditional supply chains are closed or unsecure.
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Developing Emergency Pharmaceutical Supply Chains in Conflict Zones: What Field Experience in the Middle East Concentrate in Emergence
Vol.1(2); Pages:25-33. Published on August-2025
Abstract
One of the shared experiences of actors in humanitarian activity is the delivery of necessary medicines in conflict zones. It is a field operational research that summarizes five years of experience in the Pharmaceutical supply chains in operation across Syria, Yemen, and Iraq. It looks through logistical solutions: decentralized warehousing, secure convoys tracked by GPS, and negotiations with local networks, to combat the threat of access blockage, looting and the collapse of infrastructure. Information was obtained based on operational records and interviews among pharmacists with emphasis on prevalence of stock-out, delivery efficiency and loss. The results were that the stock-out was decreased by 42 percent and that deliveries were 30 percent earlier than before. Theft or spoilage losses reduced significantly as there were improved risk-averting steps. Field employees attached significance to agile procurement and locally based trusting collaboration. The research offers instrumental information on how to enhance an effective logistics of pharmaceutics in a potentially dangerous region and suggests a duplicable model that an organization with humanitarian purposes could apply to a volatile environment.
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The Importance of Field Pharmacists in The Medicines Shortage in The Event of Massive Refugee Disaster: A Transnational Investigation
Vol.1(2); Pages:34-41. Published on August-2025
Abstract
Shortage of medication is a common problem in the event of a mass refugee flow and it interferes with the treatment of chronic and acute diseases. This transnational observational design studies how field pharmacists can assist medicine supply in refugee camps in Poland, Romania and Ghana between 2022 and 2024. The information obtained was based on 14 camps and recorded practices in pharmacist led interventions as therapeutic substitution, emergency compounding of essential medication, and education to the patients. Pharmacists aligned with NGOs and national institutions to make the procurement process faster and use the limited resources efficiently. Results demonstrated an unfilled prescription to have reduced by 37 percent and 21 percent enhancement in treatment adherence after the intervention. The characteristics of pharmacists agility in the adaptation of the clinical procedures and communicating risk to vulnerable populations were highlighted through the field interviews. Such results reaffirm the importance of including pharmacists in emergency health planning and particularly where official healthcare systems are already overloaded.
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Issue 1 JANUARY- JUNE 2025
Volume 1(Issue 1) JANUARY- JUNE 2025 Research Articles
Enhancing Cancer Treatment with Circadian-Timed Drug Delivery: Chronotherapeutics in Oncology
Vol.1(1); Pages:1-8. Published on June-2025
Abstract
Treatments for cancer have advanced greatly lately, yet the side effects can still reduce what the patient enjoys in life. Because of this, chronopharmacology now exists to help match cancer treatments to the patient’s circadian cycles. It investigates how the circadian clock relates to cancer susceptibility, the actions of clock genes in both cancer prevention and suppression and how timed medications might improve specific types of cancer therapies. Additionally, it reviews how findings on circadian rhythms can be used in palliative medicine and hormone treatments, as well as how treatments can be adjusted to meet the needs of each patient. Regulatory and ethical aspects related to chronopharmacology are studied. By relying on chronopharmacology, doctors may provide better and more personalized cancer treatments that help improve patient quality of life.
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Circadian Glucocorticoid Signaling Promotes the Use of Cardiac Glucose via the Regulation of Intrinsic Cardiomyocyte Genes
Vol.1(1); Pages:9-17. Published on June-2025
Abstract
Treatments for cancer have advanced greatly lately, yet the side effects can still reduce what the patient enjoys in life. Because of this, chronopharmacology now exists to help match cancer treatments to the patient’s circadian cycles. It investigates how the circadian clock relates to cancer susceptibility, the actions of clock genes in both cancer prevention and suppression and how timed medications might improve specific types of cancer therapies. Additionally, it reviews how findings on circadian rhythms can be used in palliative medicine and hormone treatments, as well as how treatments can be adjusted to meet the needs of each patient. Regulatory and ethical aspects related to chronopharmacology are studied. By relying on chronopharmacology, doctors may provide better and more personalized cancer treatments that help improve patient quality of life.
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Medical Students’ Knowledge and Awareness of Chronopharmacology: A Cross-Sectional Viewpoint
Vol.1(1); Pages:18-25. Published on June-2025
Abstract
The way chronopharmacology studies 24-hour body rhythms helps achieve good results in therapy and reduce drug side effects. While chronopharmacological research is rising in clinical medicine, it’s unclear how well medical students are aware of these principles. The purpose of this study is to review how much undergraduate medical students know about chronopharmacology. Participants were asked to complete a structured survey about their sleep rhythms, when drugs are administered and why. Initial research found that people have limited knowledge about chronopharmacology, showing it should be part of what doctors and pharmacists learn. Improving knowledge here can make a big difference in the way clinicians make decisions and treat patients.
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Modeling Intracellular Signal Transduction Pathways Using Computational Systems Biology
Vol.1(1); Pages:26-32. Published on June-2025
Abstract
Analysis of signal transduction pathways with computational tools has revealed many important details about how cells are regulated. Researchers use high-throughput data together with mathematical models and simulations to project cellular actions to changes in the environment and genes. They give experts a mathematical approach to look at the movement of information in MAPK, PI3K-Akt and calcium signaling over time and space. By doing this, new drug targets are discovered, new hypothesis are created and synthetic biological circuits are built, preparing medicine for personalization and a shift toward systems-based treatments.
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Mathematical Simulation of Aspirin and Valsartan’s Circadian Dependent Antihypertensive Effects
Vol.1(1); Pages:33-40. Published on June-2025
Abstract
Tailoring when drugs are given what’s called chronotherapy has become essential for making antihypertensive treatments more effective. Valsartan, an ARB, as well as aspirin, often taken for cardiovascular prevention, show changed effects over time because of the daily rhythms of blood pressure and platelet stickiness. The investigation explores just how valsartan and aspirin affect blood pressure at each time of day through a detailed model that combines body rhythms, drug absorption and action on the body. The model uses ODEs and simulates populations to follow the changing effects of drugs on endogenous rhythms in the renin-angiotensin system and blood vessels. Published results from clinical trials and in vivo studies were applied to set up and check the model. Results from simulations show that giving valsartan in the evening reduces blood pressure overnight, in harmony with the body’s natural clock, while on the other hand, aspirin achieves its strongest impact on platelets and weakest on blood pressure when taken in the early morning. Following chronobiology rules, mosquitocides used simultaneously demonstrate advantages over their single use. The findings of this research show that the right administration timing plays a vital role and gives doctors tips on forming regimens to better help people with hypertension and reduce heart risk. It allows clinicians to predict the best way to schedule treatment for individual patients.
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