The International Journal of Pediatric Pharmacy Innovations and Care (IJPPIC) is committed to providing timely access to quality research and clinical insights that contribute to the advancement of pediatric pharmacy. Each issue contains peer-reviewed articles that reflect ongoing developments, innovative practices, and emerging challenges in the field.
Featured Articles in the Latest Issue
- Volume 2 (Issue 1) JANUARY- JUNE 2026
Research Articles
Optimization of Age-Appropriate Liquid Formulations for Pediatric Antiepileptic Therapy
Vol.2(1); Pages:1-10. Published on April-2026
Abstract
The development of age-appropriate liquid formulations remains a critical challenge in pediatric antiepileptic therapy due to variability in drug stability, palatability, and bioavailability. This study aimed to optimize a liquid formulation of a commonly prescribed antiepileptic drug to enhance therapeutic adherence and pharmacokinetic consistency in children aged 2–10 years. Various excipient combinations were evaluated to achieve stability under different storage conditions while maintaining acceptable taste profiles. Pharmacokinetic modeling was conducted using simulated pediatric physiological parameters, followed by in vitro dissolution testing. Results demonstrated that the optimized formulation significantly improved drug solubility and stability over a 60-day period, with minimal degradation. Palatability assessments indicated higher acceptance rates compared to conventional formulations. The study underscores the importance of integrating pharmaceutical innovation with pediatric-specific considerations to improve treatment outcomes. These findings provide a foundation for further clinical validation and highlight the role of tailored formulations in pediatric epilepsy management.
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Adherence-Focused Management Strategies in Paediatric Asthma Therapy
Vol.2(1); Pages:11-20. Published on April-2026
Abstract
Medication adherence in pediatric asthma remains suboptimal, contributing to increased morbidity and healthcare utilization. This prospective cohort study assessed the effectiveness of structured pharmacist-led interventions in improving adherence among children aged 6–12 years diagnosed with moderate persistent asthma. The intervention included personalized counseling, digital reminder tools, and caregiver education sessions. Adherence rates were measured using pharmacy refill data and electronic monitoring devices over a three-month period. Results indicated a statistically significant improvement in adherence among the intervention group compared to baseline levels. Additionally, participants demonstrated reduced frequency of asthma exacerbations and emergency visits. Caregiver engagement emerged as a critical determinant of adherence success. The findings suggest that integrating pharmacist-led interventions into routine pediatric asthma care can substantially enhance medication adherence and clinical outcomes. Future research should explore scalability and long-term sustainability of such interventions across diverse healthcare settings.
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Neonatal Antibiotic Prescribing Beyond Label Indications: A Safety and Risk Perspective
Vol.2(1); Pages:21-30. Published on May-2026
Abstract
Off-label antibiotic use is prevalent in neonatal intensive care units (NICUs) due to limited pediatric-specific clinical data. This retrospective observational study evaluated the safety profile of commonly used off-label antibiotics in neonates across three tertiary care hospitals. Medical records of 250 neonates were analyzed to identify adverse drug reactions (ADRs), dosing variations, and clinical outcomes. The study found that while off-label prescribing was necessary in many cases, it was associated with a moderate incidence of ADRs, primarily gastrointestinal disturbances and renal function alterations. Variability in dosing practices was observed, reflecting the absence of standardized pediatric guidelines. Despite these concerns, most adverse effects were manageable and did not result in long-term complications. The study emphasizes the urgent need for evidence-based dosing guidelines and enhanced pharmacovigilance in neonatal populations. Strengthening regulatory frameworks and encouraging pediatric-specific clinical trials are essential to ensure safer antibiotic use in NICUs.
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Impact of Pharmacogenomic Testing on Pediatric Oncology Drug Dosing
Vol.2(1); Pages:31-39. Published on May-2026
Abstract
Pharmacogenomic variability significantly influences drug response in pediatric oncology, necessitating personalized dosing strategies. This randomized controlled trial investigated the clinical impact of pharmacogenomic-guided dosing compared to standard dosing protocols in children undergoing chemotherapy. A total of 120 pediatric patients were randomly assigned to either the intervention group, receiving genotype-informed dosing, or the control group. Key outcomes included incidence of adverse drug reactions, treatment efficacy, and hospitalization duration. The intervention group demonstrated a notable reduction in severe adverse events and improved therapeutic response rates. Additionally, pharmacogenomic testing facilitated more precise dose adjustments, minimizing toxicity without compromising efficacy. The findings highlight the transformative potential of integrating pharmacogenomics into pediatric oncology practice. Broader implementation of such approaches could enhance treatment safety and effectiveness, although cost and accessibility remain challenges that warrant further investigation.
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Development of Pediatric-Friendly Oral Thin Films for Nutritional Supplement Delivery
Vol.2(1); Pages:40-48. Published on June-2026
Abstract
Oral thin films (OTFs) have emerged as a promising drug delivery system for pediatric populations due to their ease of administration and improved compliance. This study focused on the development and evaluation of OTFs for delivering essential nutritional supplements to children. Various polymer matrices and plasticizers were tested to optimize film strength, disintegration time, and nutrient stability. In vitro evaluations demonstrated rapid disintegration within 30 seconds and uniform nutrient across films. Stability testing confirmed minimal degradation under controlled environmental conditions. Sensory analysis indicated high acceptability among simulated pediatric taste profiles. The developed OTFs offer a viable alternative to traditional dosage forms, particularly for children with swallowing difficulties. This innovation holds potential for improving nutritional supplementation adherence and overall pediatric health outcomes. Further clinical studies are recommended to validate in vivo performance and long-term benefits.
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