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Tailoring when drugs are given what’s called chronotherapy has become essential for making antihypertensive treatments more effective. Valsartan, an ARB, as well as aspirin, often taken for cardiovascular prevention, show changed effects over time because of the daily rhythms of blood pressure and platelet stickiness. The investigation explores just how valsartan and aspirin affect blood pressure at each time of day through a detailed model that combines body rhythms, drug absorption and action on the body. The model uses ODEs and simulates populations to follow the changing effects of drugs on endogenous rhythms in the renin-angiotensin system and blood vessels. Published results from clinical trials and in vivo studies were applied to set up and check the model. Results from simulations show that giving valsartan in the evening reduces blood pressure overnight, in harmony with the body’s natural clock, while on the other hand, aspirin achieves its strongest impact on platelets and weakest on blood pressure when taken in the early morning. Following chronobiology rules, mosquitocides used simultaneously demonstrate advantages over their single use. The findings of this research show that the right administration timing plays a vital role and gives doctors tips on forming regimens to better help people with hypertension and reduce heart risk. It allows clinicians to predict the best way to schedule treatment for individual patients.