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Volume 1
Issue 2 JULY– DECEMBER 2025
Volume 1 (Issue 2) JULY– DECEMBER 2025 Research Articles
Pharmacist-Led Oral Chemotherapy Monitoring: effect on adherence and management of toxicity in outpatient breast cancer patients
Vol.1(2); Pages:1-11. Published on July-2025
Abstract
Oral chemotherapy has revolutionized the practice of cancer treatment but has created new issues of drug adherence and adverse event management, particularly in the outpatient clinic. The research is the assessment of the effects of a pharmacist-driven monitoring program on adherence and management of toxicity in breast cancer patients who access oral chemotherapy. Eighty patients undergoing capecitabine and palbociclib were assigned to a 12-week intervention that comprised of weekly telephonic follow-ups, evaluations of side effects, and education concerning the medication. The adherence to medication was assessed with the use of the Morisky Medication Adherence Scale (MMAS-8), and the toxicity was monitored according to the CTCAE v5.0. At the end of the results, it was shown that there was statistically significant improvement in medication adherence (p < 0.01) and decrease in Grade 3 or higher toxicities. Also, patients expressed higher satisfaction with the care they received and were more supported by the health care team. These results highlight the need of increasing the role of oncology pharmacist in the management of oral chemotherapy to assure patient safety and better treatment outcomes in ambulatory cancer care.
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Clinical Pharmacist-Led Oral Chemotherapy Adherence Programs among Patients with Breast Cancer: A Multicentric Study
Vol.1(2); Pages:12-20. Published on July-2025
Abstract
Oral chemotherapy has brought a very positive shift in treating cancer; enabling home based treatment, however there are major issues of adherence and managing toxicity. The study was a multicentered, interventional research study to understand how therapeutic treatment adherence programs discussed by clinical pharmacists in three oncology centers in Switzerland, India, and South Africa yielded. One hundred and forty breast cancer patients with oral chemotherapy (capecitabine or palbociclib) were provided structured counseling with follow-ups every two weeks and the monitoring of adverse events during the 12 weeks. Toxicity and hospitalization data were used to measure clinical outcomes of safety, whereas the MMAS-8 scale and pharmacy refill reports were used to evaluate adherence. The outcomes were 22%-enhanced adherence scores (p < 0.001), less rare adverse events (Grade 3 or more ride), and improved patient satisfaction, with 87% of participants claiming that pharmacist assistance is an essential part of their treatment. Results highlight the importance of pharmacist-led interventions in safely, effectively and patient-centering oral chemotherapy management.
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An in vivo survey of using pharmacist-led antiemetic stewardship to get rid of chemotherapy-induced nausea and vomiting
Vol.1(2); Pages:21-30. Published on July-2025
Abstract
Chemotherapy induced nausea and vomiting (CINV) affect strongly the patient adherence, the success of treatments, and patient quality of life. This observational study in the real world evaluated the effectiveness of the pharmacist-administered antiemetic stewardship programs in three hospitals in the country of Sweden, Egypt, and the UAE. The intervention consisted of pharmacist-led choice of antiemetic regimen in accordance with international guidelines, pre-treatment education of patients and active monitoring of breakthrough CINV. There were 210 cancer patients undergoing highly emetogenic chemotherapeutic agent like cisplatin and doxorubicin, and each patient underwent four cycles. Investigated outcomes showed a 28 percent improved complete response, that is, no nausea, no vomiting and the absence of rescue medication, versus base (p
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Outcomes with fluoropyrimidine chemotherapy: Pharmacogenomic Guided Dosing in Colorectal Cancer
Vol.1(2); Pages:31-39. Published on August-2025
Abstract
Pharmacogenomic-based dosing allows fluoropyrimidines therapy of colorectal cancer to be used safely and more effectively due to consideration of individual genetic variation. Our study was a prospective clinical trial that recruited 120 patients in oncology centers in Italy and Japan to compare pre-treatment DPYD and TYMS genotype to improve clinical utility of genotyping in the pre-treatment setting. Patients were dosed with fluoropyrimidine-based chemotherapy presumptively adjusted to their pharmacogenomic profile whereas outcomes were compared to a historical control group with matched pharmacogenomic dosing. The pharmacogenomic-guided cohort reported 32 percent fewer Grade 34 toxicities ( p < 0.001) than patients with a typical algorithm and increased adherence to their regimen together with a small, but statistically significant progression-free survival advantage. There was also a much higher satisfaction rating of personalized therapy as reported by the patient. This study justifies the standard implementation of pharmacogenomic screening in treatment plans, where colorectal cancer is concerned, in order to promote safety and increase efficacy of treatment.
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Analysis of clinical pharmacist intervention in minimizing drug-drug interactions of patients on targeted oral oncology drugs
Vol.1(2); Pages:40-50. Published on August-2025
Abstract
Drug-drug interactions (DDIs) are a considerable challenge in the context of the use of targeted oral anticancer therapies, such as tyrosine kinase inhibitors (TKIs) and CDK4/6 inhibitors, since their metabolism is complex and polypharmacy is taken. The objective of the proposed study was to conduct a prospective observational study using an intervention implemented by clinical pharmacists to help in the reduction of DDIs in 185 patients in two tertiary cancer patients in Germany and Brazil. Carefully performed medication reviews, the degree of interaction between medications was established with the assistance of Lexicomp 1 and Micromedex 1, and recommendations addressed to oncologists were offered by pharmacists. They were identified 312 potential DDIs (clinically significant in 76 percent of cases). Therapy was reduced or changed in accordance with interventions in 71 percent of the cases or doses were changed. Subsequent care reported 40 percent less adverse drug events caused by the interactions and thereby increasing patient safety and treatment compliance.
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Issue 1 JANUARY- JUNE 2025
Volume 1(Issue 1) JANUARY- JUNE 2025 Research Articles
New Developments in Community Pharmacy Practice in the United States: Increasing the Function of Community-Based Pharmacists
Vol.1(1); Pages:1-8. Published on June-2025
Abstract
Changing healthcare needs, new policies and efforts to provide patients with cheaper and more accessible care are bringing about a revolution in community pharmacy practice in the United States. As a result of this change, community-based pharmacists now provide comprehensive clinical services, manage ongoing diseases, prevent illnesses, supervise medication therapy, give vaccinations and extend public health outreach. Thanks to new service models such as appointments for medication order synchronization, team agreements and including digital solutions, pharmacists play an active role in supporting all members of a healthcare team. They are especially useful in under-served regions, since CBPPs work to address important shortages in primary care. Covid-19 emphasized the important role of pharmacists, who saw both advantages in regulations and a broader area of work. Even so, there are hurdles to overcome in getting reimbursed, being recognized as healthcare providers and creating standard training across countries. It brings together fresh improvements, current policies and research on the expanding clinical, financial and public health roles of community pharmacists in the U.S. and recommends building a sustainable system to ensure their full inclusion in healthcare.
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Policy and Goals for Community Pharmacists’ Integration into Germany’s Primary Healthcare System
Vol.1(1); Pages:9-16. Published on June-2025
Abstract
Community pharmacists’ role in primary healthcare is now more important and understood in Germany. Previously focused only on medications, the new perspective for pharmacists in Germany helps them provide additional services, handle chronic illnesses, run vaccination clinics and review patient medications. Because of the 2020 Apothekenstarkungsgesetz (Pharmacy Strengthening Act), pharmacists are now being enlisted to handle common treatments, ease the burden on doctors and improve patient care. It studies how pharmacists can be integrated into Germany’s healthcare team by explaining the overall system setup, help needed from laws and the policies being considered. It discusses the move to make community pharmacies central health centers in rural areas, so that health promotion, early diagnosis and adherence care become possible. Even though reforms are still at the beginning, pilot programs and backing in the Parliament are clear signs that officials are planning to change the healthcare system to make it more integrated and aligned with EU-wide trends.
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Pharmacy Education’s Transformative Forces: Crossing Academic, Social, Technological, Economic, and Political Boundaries
Vol.1(1); Pages:17-25. Published on June-2025
Abstract
Education in pharmacy is being greatly changed by the way academic, social, technological, economic and political forces come together. All over the world, these factors are changing what we teach, how it is delivered, what schools focus on and what professional staff are expected to do. Academics today are turning to competency-based learning and encourage students from different fields to work together, so educators need new ways to teach and test knowledge. The awareness of health inequalities, along with a new role for pharmacists in local communities, has resulted in a major focus on cultural competence and patient care in pharmacy schools. Following improvements in AI, training by simulation and digital tools, students in pharmacy are now taught with more real-world examples. Money-saving changes in healthcare are prompting universities and institutes to work more efficiently and clearly show their program results. Political changes to healthcare are shaping the standards, space for practice and licensing of medical professionals. Pharmacy education has a chance to respond to new challenges and open up fresh, unparalleled opportunities to strengthen and modernize itself. Working on each of these areas at once helps schools and educators get ready to pass down the skills needed by current healthcare systems.
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Application of ARIA Guidelines in Community Pharmacies for the Management of Allergic Rhinitis
Vol.1(1); Pages:26-32. Published on June-2025
Abstract
Allergic Rhinitis (AR) is widespread and is not always recognized for its major effects on people’s lives, how productive they can be and their other health problems like asthma and sinusitis. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines are supported by experts worldwide and by the World Health Organization, helping to guide how AR should be diagnosed and treated. The article looks at using ARIA guidelines in community pharmacy, offering pieces of advice for better detection of early signs, education for patients and optimal drug choices. Pharmacists are now a key part of primary care, so using ARIA for pharmacy practice aids in personal care, helps patients look after themselves and makes teamwork with doctors and allergists much simpler. With the help of specific protocols, digital systems and involvement of everyone in decisions, pharmacists make sure ARIA guidelines are followed and care is improved. This paper covers real-world multiple challenges, recommended ways to tackle them and inspiring stories from different healthcare systems, in favor of using community pharmacies to deliver AR care in an integrated form.
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Influence of School Climate and Leadership on Indonesian Vocational Pharmacy Teachers’ Productivity
Vol.1(1); Pages:33-40. Published on June-2025
Abstract
We investigate in this research how the principal’s actions and the school climate affect the productivity of vocational pharmacy teachers in Indonesia. Because vocational education helps produce highly skilled pharmaceutical workers, knowing what affects teachers’ productivity is key. The survey method is used as the study’s main approach and data are gathered from vocational pharmacy teachers in different areas of Indonesia. The research considers the effects of transformational, transactional and instructional leadership on teachers’ motivation, degree of satisfaction with their job and total performance. Furthermore, the research examines the school climate with regard to cooperation among staff, trust, safety, efforts to be creative and management support to find out how it impacts teaching. Leadership and climate are studied statistically, using multiple regression and path analysis, to determine their impact on teachers’ output. It was found that both the style of the principal and a positive moral environment in the school help raise employees’ productivity. Transformation leadership stands out, proving that supportive and inspiring leaders are particularly important in vocational fields. The findings suggest that specific leadership and school environment programs would improve both the effectiveness and well-being of vocational pharmacy educators. This research gives useful advice to policymakers, school administrators and teacher institutions to enhance the quality of vocational education in Indonesia.
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