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Analysis shows that Restless Leg Syndrome (RLS) known as Willis-Ekbom Disease appears frequently yet remains unknown by medical professionals when dealing with chronic kidney disease (CKD) and dialysis patients because prevalence studies indicate between 15% to 45% cases. The symptoms of RLS include an uncontrollable need to move the legs which worsen when people rest and during nighttime periods thus resulting in severe disturbance of sleep patterns with fatigue throughout the day coupled with depression along with reduced quality of life (QoL).Scientific studies today demonstrate the value of combining medication-based approaches with non-medicine treatments in RLS management for this patient group. Medical treatment options that include dopaminergic agents together with gabapentin and opioids demonstrate moderate effectiveness but patients need to face the risks of adverse effects alongside drug tolerance development. The promise of managing RLS in individuals under dialysis treatment comes from low-risk non-pharmacological methods which include aerobic and stretching exercises and foot massage in combination with Kinesio taping and virtual-reality-assisted aerobic therapy and acupoint stimulation techniques. The available treatments demonstrate major positive effects which help patients with hemodialysis get better sleep and decrease their symptoms and improve their quality of life.Studies demonstrate that RLS symptoms become more severe because of anemia conditions and iron deficiencies in addition to when someone receives dialysis and experiences psychological stress. The treatment of patients with RLS should incorporate continuous monitoring coupled with sleep evaluations coupled with individualized behavioral changes together with standard medical care. New research shows that treating Restless Legs Syndrome requires multiple healthcare disciplines in dialysis programs to improve both patient health and prolonged treatment results.